2000–01 UEFA Cup second round
The second round of the 2000–01 UEFA Cup began on 23 October 2000. The round included 48 winners from the first round.
Seeding
    
| Seeded teams | Group | Unseeded teams | ||
|---|---|---|---|---|
| Team | Coefficient rating | Team | Coefficient rating | |
| 79.964 | 1 | 27.333 | ||
| 56.562 | 18.433 | |||
| 53.799 | 14.525 | |||
| 43.201 | 12.708 | |||
| 34.250 | 11.000 | |||
| 32.201 | 8.062 | |||
| 78.964 | 2 | 26.062 | ||
| 60.333 | 22.250 | |||
| 49.728 | 14.562 | |||
| 43.433 | 13.767 | |||
| 34.799 | 10.500 | |||
| 29.201 | 9.087 | |||
| 75.333 | 3 | 24.433 | ||
| 61.275 | 17.708 | |||
| 46.364 | 14.500 | |||
| 43.964 | 14.000 | |||
| 42.201 | 11.250 | |||
| 29.799 | 9.087 | |||
| 65.964 | 4 | 25.250 | ||
| 64.364 | 22.275 | |||
| 48.638 | 14.433 | |||
| 46.201 | 14.050 | |||
| 32.525 | 10.500 | |||
| 29.799 | 10.416 | |||
Matches
    
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg | 
|---|---|---|---|---|
| Iraklis  | 
4–5 | 1–3 | 3–2 | |
| Osijek  | 
4–1 | 2–1 | 2–0 | |
| Udinese  | 
1–3 | 1–0 | 0–3(aet) | |
| Werder Bremen  | 
9–3 | 4–1 | 5–2 | |
| Halmstad  | 
4–5 | 3–2 | 1–3 | |
| AEK Athens  | 
6–2 | 5–0 | 1–2 | |
| Hertha BSC  | 
4–2 | 3–1 | 1–1 | |
| Lillestrøm  | 
3–5 | 1–3 | 2–2 | |
| Internazionale  | 
(a)1–1 | 0–0 | 1–1 | |
| Bordeaux  | 
3–2 | 1–1 | 2–1(aet) | |
| Espanyol  | 
4–1 | 4–0 | 0–1 | |
| Boavista  | 
1–2 | 0–1 | 1–1 | |
| Tirol Innsbruck  | 
2–3 | 1–0 | 1–3 | |
| Red Star Belgrade  | 
4–5 | 1–0 | 0–31 | |
| Lokomotiv Moscow  | 
3–1 | 1–0 | 2–1 | |
| Basel  | 
1–3 | 1–2 | 0–1 | |
| Liverpool  | 
4–2 | 1–0 | 3–2 | |
| Rayo Vallecano  | 
(a)2–2 | 1–0 | 1–2 | |
| Lausanne  | 
3–2 | 1–0 | 2–2 | |
| Nantes  | 
3–1 | 2–1 | 1–0 | |
| Club Brugge  | 
3–2 | 2–1 | 1–1 | |
| Parma  | 
2–1 | 2–0 | 0–1 | |
| OFI Crete  | 
3–6 | 2–2 | 1–4 | |
| Wisła Kraków  | 
0–3 | 0–0 | 0–3 | 
1 This 2nd leg match in Vigo actually ended with the score 5–3 for the hosts Celta, but was later officially recorded as 3–0 walkover since it was discovered that Red Star fielded two suspended players.
First leg
    
| Iraklis  | 1–3 | |
|---|---|---|
| Konstantinou  | 
Report UEFA Report | Klose  Hristov Tavlaridis  | 
| Osijek  | 2–1 | |
|---|---|---|
| Bjelica  | 
Report UEFA Report | Radovic  | 
| Udinese  | 1–0 | |
|---|---|---|
| Margiotta  | 
Report UEFA Report | 
| Werder Bremen  | 4–1 | |
|---|---|---|
| Ernst  Herzog Baumann Bode  | 
Report UEFA Report | Sonck  | 
| Halmstad  | 3–2 | |
|---|---|---|
| M. Svensson  Selakovic R. Andersson  | 
Report UEFA Report | Max  Häßler  | 
| AEK Athens  | 5–0 | |
|---|---|---|
| Nikolaidis  Zikos  | 
Report UEFA Report | 
| Hertha BSC  | 3–1 | |
|---|---|---|
| Preetz  Beinlich Reiss  | 
Report UEFA Report | Piskuła  | 
| Lillestrøm SK  | 1–3 | |
|---|---|---|
| Helland  | 
Report UEFA Report | Begoña  Téllez Contra  | 
| Tirol Innsbruck  | 1–0 | |
|---|---|---|
| Mair  Baur  | 
Report UEFA Report | Todt  | 
| Liverpool  | 1–0 | |
|---|---|---|
| Heskey  | 
Report UEFA Report | 
| Rayo Vallecano  | 1–0 | |
|---|---|---|
| Quevedo  Poschner  | 
Report UEFA Report | 
| Nantes  | 2–1 | |
|---|---|---|
| Ziani  Gillet  | 
Report UEFA Report | Ferenczi  | 
| Club Brugge  | 2–1 | |
|---|---|---|
| Lembi  Vermant  | 
Report UEFA Report | Amoah  | 
| Parma  | 2–0 | |
|---|---|---|
| Amoroso  | 
Report UEFA Report | 
| OFI Crete  | 2–2 | |
|---|---|---|
| Kolitsidakis  Mauro Silva  | 
Report UEFA Report | Nečas  Rada  | 
Second leg
    
| Kaiserslautern  | 2–3 | |
|---|---|---|
| Koch  Djorkaeff  | 
Report UEFA Report | Konstantinou  Ederson  | 
Kaiserslautern win 5-4 on aggregate
| Rapid Wien  | 0–2 | |
|---|---|---|
| Report UEFA Report | Bjelica  Jukić  | 
Osijek win 4-1 on aggregate
PAOK win 3–1 on aggregate
| Genk  | 2–5 | |
|---|---|---|
| Thijs  Zokora  | 
Report UEFA Report | Pizarro  Stalteri Maksymov  | 
Werder Bremen win 9–3 on aggregate
| 1860 München  | 3–1 | |
|---|---|---|
| Max  Agostino  | 
Report UEFA Report | R. Andersson  | 
1860 München win 5–4 on aggregate
| Herfølge  | 2–1 | |
|---|---|---|
| Jakobsen  Hermansen  | 
Report UEFA Report | Petkov  | 
AEK Athens win 6–2 on aggregate
| Amica Wronki  | 1–1 | |
|---|---|---|
| Krol  | 
Report UEFA Report | Veit  | 
Hertha BSC win 4–2 on aggregate
| Alavés  | 2–2 | |
|---|---|---|
| Magno  Epitié  | 
Report UEFA Report | Strand  Søgård  | 
Alavés win 5–3 on aggregate
| Vitesse Arnhem  | 1–1 | |
|---|---|---|
| Peeters  | 
Report UEFA Report | Šimić  | 
1–1 on aggregate. Internazionale win on away goals
Bordeaux win 3–2 on aggregate
| Grazer AK  | 1–0 | |
|---|---|---|
| Ehmann  | 
Report UEFA Report | 
Espanyol win 4–1 on aggregate
Roma win 2–1 on aggregate
| Stuttgart  | 3–1 | |
|---|---|---|
| Schneider  Ganea Pinto  | 
Report UEFA Report | Brzęczek  | 
Stuttgart win 3–2 on aggregate
| Celta Vigo  | 5–3 | |
|---|---|---|
| Catanha  López McCarthy  | 
Report UEFA Report | Drulić  | 
Celta were awarded a 3–0 victory for the second leg as Red Star fielded ineligible players, therefore winning 3–1 on aggregate
| Inter Bratislava  | 1–2 | |
|---|---|---|
| Čišovský  | 
Report UEFA Report | Chugainov  Janashia  | 
Lokomotiv Moscow win 3–1 on aggregate
| Feyenoord  | 1–0 | |
|---|---|---|
| Kalou  | 
Report UEFA Report | 
Feyenoord win 3–1 on aggregate
| Slovan Liberec  | 2–3 | |
|---|---|---|
| Štajner  Breda  | 
Report UEFA Report | Barmby  Heskey Owen  | 
Liverpool win 4–2 on aggregate
| Viborg  | 2–1 | |
|---|---|---|
| Fernandez  Pedersen  | 
Report UEFA Report | Míchel  | 
2–2 on aggregate Rayo Vallecano win on away goals
| Ajax  | 2–2 | |
|---|---|---|
| Arveladze  Van der Gun  | 
Report UEFA Report | Mazzoni  Kuźba  | 
Lausanne win 3–2 on aggregate
| MTK Budapest  | 0–1 | |
|---|---|---|
| Report UEFA Report | Monterrubio  | 
Nantes win 3–1 on aggregate
| St. Gallen  | 1–1 | |
|---|---|---|
| Amoah  | 
Report UEFA Report | Mendoza  | 
Club Brugge win 3–2 on aggregate
| Dinamo Zagreb  | 1–0 | |
|---|---|---|
| Šokota  | 
Report UEFA Report | Sartor  | 
Parma win 2–1 on aggregate
| Slavia Prague  | 4–1 | |
|---|---|---|
| Kuchař  Zelenka Digozis  | 
Report UEFA Report | Muñoz  | 
Slavia Prague win 6–3 on aggregate
| Porto  | 3–0 | |
|---|---|---|
| Pena  Alenichev  | 
Report UEFA Report | 
Porto win 3–0 on aggregate
References
    
- Verein "Basler Fussballarchiv”. "Basel-Feyenoord Telegram". Verein "Basler Fussballarchiv”. Retrieved 2018-11-16.
 - Verein "Basler Fussballarchiv”. "Feyenoord-Basel Telegram". Verein "Basler Fussballarchiv”. Retrieved 2018-11-16.