8-oxo-dGDP phosphatase
8-oxo-dGDP phosphatase (EC 3.6.1.58, NUDT5) is an enzyme with systematic name 8-oxo-dGDP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 8-oxo-dGDP + H2O 8-oxo-dGMP + phosphate
| 8-oxo-dGDP phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.58 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP.
References
- Ishibashi T, Hayakawa H, Ito R, Miyazawa M, Yamagata Y, Sekiguchi M (2005). "Mammalian enzymes for preventing transcriptional errors caused by oxidative damage". Nucleic Acids Research. 33 (12): 3779–84. doi:10.1093/nar/gki682. PMC 1174896. PMID 16002790.
- Ishibashi T, Hayakawa H, Sekiguchi M (May 2003). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Reports. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
- Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H (October 2009). "NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity". DNA Repair. 8 (10): 1250–4. doi:10.1016/j.dnarep.2009.07.011. hdl:2115/39841. PMID 19699693.
- Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H (June 2011). "Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein". Journal of Biochemistry. 149 (6): 731–8. doi:10.1093/jb/mvr028. PMID 21389046.
- Zha M, Zhong C, Peng Y, Hu H, Ding J (December 2006). "Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity". Journal of Molecular Biology. 364 (5): 1021–33. doi:10.1016/j.jmb.2006.09.078. PMID 17052728.
External links
- 8-oxo-dGDP+phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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