Strictosidine beta-glucosidase
3α(S)-strictosidine β-glucosidase (EC 3.2.1.105) is an enzyme with systematic name strictosidine β-D-glucohydrolase.[1][2][3] It catalyses the following chemical reaction:
- strictosidine + H2O D-glucose + strictosidine aglycone
| 3α(S)-strictosidine β-glucosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.1.105 | ||||||||
| CAS no. | 73379-57-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. It participates in indole and ipecac alkaloid biosynthesis.
Strictosidine is a precursor of indole alkaloids.
References
- Hemscheidt T, Zenk MH (February 1980). "Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures". FEBS Letters. 110 (2): 187–91. doi:10.1016/0014-5793(80)80069-X. PMID 6768587.
- Luijendijk TJ, Stevens LH, Verpoorte R (1998). "Purification and characterisation of strictosidine β-D-glucosidase from Catharanthus roseus cell suspension cultures". Plant Physiol. Biochem. 36 (6): 419–425. doi:10.1016/S0981-9428(98)80205-2.
- Barleben L, Ma X, Koepke J, Peng G, Michel H, Stöckigt J (February 2005). "Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1747 (1): 89–92. doi:10.1016/j.bbapap.2004.09.026. PMID 15680242.
External links
- 3alpha(S)-strictosidine+beta-glucosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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