There are many other options other than Django. However:
You can make your own SQL queries in Django. Here is the documentation for extra(). extra() lets you make extra SQL calls on top of the ORM.
If you want to make raw SQL queries, bypassing the ORM entirely, you can do so with django.db. See this article for examples.
That said, other options aside from Django if you still want to use a framework:
- Turbogears
- Pylons
- Web2Py
- Zope3
- Plone/Zop2
See this list for a listing of more frameworks.
Now, if you don't want to use a ORM and just want o make SQL calls directly, Python also has the ability to interact with a database. See this page on the Python wiki.