Adapalene/benzoyl peroxide

Adapalene/benzoyl peroxide
Combination of
AdapaleneRetinoid
Benzoyl peroxidePeroxide
Clinical data
Trade namesEpiduo
Routes of
administration		Epicutaneous
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
KEGG
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Adapalene/benzoyl peroxide is a prescription medication combination for the treatment of severe acne vulgaris; marketed by Galderma under the trade name Epiduo.[1] Its trade name in Canada is TactuPump, where it was previously known as Tactuo.[2] It consists of a combination of adapalene (0.1%) and benzoyl peroxide (2.5%) in a topical gel formulation.[1] Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[3]

Interactions

People are advised to exercise caution in using Epiduo together with other skin products containing sulfur, resorcinol, or salicylic acid, or with medicated or abrasive dirts and cleansers.[4] Skin products with high levels of alcohol or astringents should also be avoided.[4] Using topical products with a strong drying effect in combination with Epiduo can increase irritation.[4] The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[5] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).

Side effects

Commonly reported side effects include the following:[4]

Precautions

People who use adapalene/benzoyl peroxide are advised to avoid exposure to sunlight and sunlamps, and use sunscreen when these cannot be avoided.[4]

References

  1. 1 2 "FDA OKs New Acne Gel Epiduo". Webmd.com. Retrieved 2012-01-25.
  2. ↑ "How Does Benzoyl Peroxide Work on Acne". Archived from the original on 2018-08-26. Retrieved 2018-05-27.
  3. ↑ Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
  4. 1 2 3 4 5 "Full prescribing information" (PDF). Retrieved 2012-01-25.
  5. ↑ Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.
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